GLP-1 Agonists: Are Weight Loss Injections Worth It?

June 19, 2024

Table of Contents

Additional Resources

In a world where drive-thrus beckon and office chairs seem to mold to our expanding waistlines, the allure of quick fixes for weight loss is undeniable. Enter GLP-1 agonists—the new superheroes of appetite suppression. You may know them by other names, like semaglutide, Ozempic, Mounjaro, or Wegovy.

But are they worth the cost? Do they deliver long-lasting effects? Let’s explore the science behind these injections and their potential pitfalls.

The Promise of GLP-1 Agonists

GLP-1 (glucagon-like peptide-1) agonists—the name sounds like something out of a futuristic sci-fi novel. But in reality, they’re a class of medications designed to curb hunger pangs. Picture this: You inject a tiny dose, and suddenly, that late-night pizza craving loses its grip. Sounds magical, right? Well, it kind of is.

GLP-1 is a hormone produced in your intestines after you eat. Its primary job is to regulate blood sugar levels and control appetite. When food enters your stomach, GLP-1 is released, and it signals your brain to reduce hunger and slow down digestion. Think of it as your body’s built-in portion control manager.

GLP-1 agonists are clever impostors. They mimic the effects of GLP-1 without any food entering your body. When you inject a GLP-1 agonist, it binds to GLP-1 receptors in your brain and gut. These receptors are like tiny locks waiting for the right key.

Once bound, the agonist tells your brain that you’re already full, reducing “food noise” and desire to snack on unhealthy treats. 

GLP-1 agonists suppress appetite by:

  • Slowing down stomach emptying: Food lingers longer, keeping you full.
  • Reducing food cravings: That late-night pizza? Suddenly less tempting.
  • Enhancing insulin secretion: Blood sugar stays stable, preventing sudden hunger spikes.


The result? Weight loss. You eat less, feel satisfied, and shed those extra pounds.

The Flaws of GLP-1 Agonists

But that doesn’t mean these medicines aren’t without their limitations. Let’s address the elephant in the room—the potential pitfalls:

  • Malnourishment risk: Suppressing appetite doesn’t guarantee wise food choices. Without proper nutrition, users may face malnourishment. Pairing GLP-1 agonists with a balanced diet, including leafy greens and lean proteins, is crucial.
  • Muscle atrophy: Appetite suppression isn’t picky—it affects not only fat loss but also muscle. The result can be muscle atrophy. Suddenly, lifting a grocery bag might feel like bench-pressing a car. Not ideal.
  • GI side effects: Many people using GLP-1s can suffer from mild to moderate gastrointestinal side effects, like nausea, vomiting, and diarrhea.
  • Behavior change support: Here’s the kicker. GLP-1 agonists can’t automatically teach you how to cook healthier meals or stick to an exercise routine. So, while your appetite shrinks, your habits remain untouched. While you’re taking the medicines, you may lose weight, but if you go back to old habits, you’ll likely relapse and gain some weight back. Holistic lifestyle changes are the key.

The Brain Science Behind Weight Loss

It’s as if our brain’s neural pathways cling to familiar routines, making lasting weight loss an uphill battle. But fear not—there’s a secret weapon in our arsenal: behavioral adaptation.

Imagine it as a dance; two steps forward and one step back. We fine-tune our approach, adjust our strategies, and suddenly, our brains signal approval. These behavioral tweaks, often referred to as “iteration,” hold the key to sustainable weight loss.

The Habenula: A Weighty Player

Now, let’s zoom in on an overlooked brain structure—the habenula. Nestled deep within the brain, this small but influential region plays a pivotal role in decision-making, motivation, and reward processing. Think of it as your internal compass, guiding you toward healthier choices.

Research suggests that the habenula helps regulate our responses to rewards and punishments, and an overactive habenula spells trouble. We call the habenula the “motivation kill-switch” because it slams the breaks on pleasure and motivation when we find ourselves in stressful, painful, or difficult situations where the outcome doesn’t match our goals. 

Small changes to our behaviors are less likely to be stressful, so they don’t trigger the habenula, and our motivation keeps us on track. This is why we believe so strongly in the power of the Iterative Mindset Method™.

The Power of Iteration in Behavior Change and Weight Loss

Permanent behavior change isn’t about radical shifts—it’s about iterative adjustments. We assess, tweak, practice, and learn from each step. Here’s where the magic happens:

  • Small shifts, big impact: Rather than drastic overhauls, focus on incremental changes. Swap that afternoon soda for herbal tea, or take the stairs instead of the elevator. These small shifts accumulate over time, reshaping your habits.
  • Motivation matters: Motivation isn’t a constant flame; it flickers. Harness it when it’s strong, but recognize that it waxes and wanes. During low motivation phases, rely on discipline and routine to keep moving forward.
  • Mindful choices: When faced with a food choice, pause and consider: Is this choice aligned with my long-term goals? Iteratively fine-tune your selections based on what truly nourishes your body and soul.

Evergreen Behavior Change

Behavior change isn’t a sprint; it’s a lifelong marathon. As we age and encounter different life circumstances, our strategies must adapt. Here’s the beauty of evergreen behavior change:

  • Flexibility: Life throws curveballs—new jobs, family dynamics, health challenges. An evergreen approach allows you to adjust without losing momentum. Be kind to yourself during transitions.
  • Consistency: Consistency breeds success. Whether you’re 25 or 70, the principles remain: iterate, stay motivated, and listen to your habenula’s subtle cues.

Lifelong Health and Wellness

Embrace the journey. Weight loss isn’t a finite destination; it’s a path toward lifelong health. By understanding the brain’s dance of adaptation, we unlock the potential for sustained well-being.

GLP-1 agonists offer a promising tool for weight loss, but they’re not a standalone solution. Acknowledge their flaws, nourish your body wisely, and pair them with holistic lifestyle changes. The Iterative Mindset Method™ can help you do just that. Remember, the dance of iteration leads to lasting transformation. 


Let’s start together

Get Healthy, Stay Healthy—Feel Better.

Continue Reading